Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Hydroxychloroquine azathioprine combination Normal dosage for plaquenil Hydroxychloroquine plaquenil for malaria protection Hydroxychloroquine dogbone What is Macular hole? Macular hole small break in the macula, the central area of the retina has been reported by people with rheumatoid arthritis, high blood pressure, multiple sclerosis, vitreous adhesions, age-related macular degeneration. Check the latest reports from 1,159 Macular hole patients, or browse all conditions. The actual incidence of retinal toxicity from hydroxychloroquine is difficult to pin down because there is usually a long time between being started on the drug and the start of any identifiable retinal toxicity. The overall rate of probable retinal toxicity is in the range of 1 of every 200 people treated. After prolonged use, it can sometimes damage the macula and cause central vision loss. Typically, the macula loses its orange pigment, giving the appearance of a bullseye. This is called bullseye maculopathy and is the classic finding of Plaquenil toxicity. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil toxicity macula Bull's-eye maculopathy due to hydroxychloroquine toxicity, What can Hydroxychloroquine Plaquenil do to my eyes? How to take plaquenil twice dailyCan you rheumate with plaquenilHydroxychloroquine burrelia burgdorferiAra hydroxychloroquinePlaquenil and doxycycline interaction The American Academy of Ophthalmology has suggested guidelines in order to monitor patients on hydroxychloroquine therapy, recommending a baseline dilated fundus exam, automated macular perimetry and Amsler grid testing. 3 Patients should be monitored annually, as toxicity can be irreversible and even progress after drug cessation. Common Medications That May Be Toxic to the Retina. Plaquenil Toxicity - Bennett & Bloom Eye Centers. Chloroquine and Hydroxychloroquine Toxicity Workup Approach.. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some. The side effect that is of greatest concern is retinal toxicity. Retinal toxicity of Plaquenil may manifest itself with subtle disturbances of the retinal pigment epithelium which may eventually lead to complete destruction of the macula in the form of bull’s-eye maculopathy. Hydroxychloroquine retinopathy. It is known that some people who take. hydroxychloroquine for more than five years and/or in high doses are at increased risk of. damage to their retina, the light sensitive layer of cells at the back of the eye. This is known as. retinal toxicity or retinopathy.