Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil patient information Plaquenil and wine Hydroxychloroquine plaquenil for malaria protection PLAQUENIL can lower the convulsive threshold. Co-administration of PLAQUENIL with other antimalarials known to lower the convulsion threshold e.g. mefloquine may increase the risk of convulsions. Antiepileptics. The activity of antiepileptic drugs might be impaired if co-administered with PLAQUENIL. Methotrexate Antimalarials are used extensively in both RA and SLE. The major side effect is retinal toxicity, which requires ophthalmologic monitoring every 6–12 months. The favored antimalarial is hydroxychloroquine FDA Category C, which appears to have a lower incidence of retinal toxicity. The active ingredient in hydroxychloroquine is hydroxychloroquine sulfate. 4. How does hydroxychloroquine work? Hydroxychloroquine is an antimalarial drug. It is derived from quinine and cinchonine, which were originally taken from the bark of the cinchona tree found in Peru. Antimalarials modulate or change the way the immune system works. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Antimalarials hydroxychloroquine Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus Center, Antimalarial Agent - an overview ScienceDirect Topics Hydroxychloroquine eye exam guidance ncbiChloroquine phosphate suspension ipChloroquine diphosphate autophagyWhat is hydroxychloroquine 400 mg used forHydroxychloroquine pronounce Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. Hydroxychloroquine - Wikipedia. Treatments for Rheumatoid Arthritis. Hydroxychloroquine MedlinePlus Drug Information. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. The antimalarials most often prescribed to people with lupus are Hydroxychloroquine Plaquenil® Chloroquine Aralen® Quinacrine Atabrine® 2-3; Hydroxychloroquine is prescribed the most often because it is thought to have the fewest side effects. Chloroquine and quinacrine are prescribed when hydroxychloroquine cannot be used. How does Plaquenil help me battle lupus? Antimalarials are able to help modulate the immune system. And, they have the additional benefit of not making your body more susceptible to infection a noted side effect of many other lupus medications.