Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Hydroxychloroquine for vasculities rash P62 chloroquine Plaquenil side effects percentages Does plaquenil stop joint destruction in ra Patients who get a drug exanthem with hydroxychloroquine may be able to tolerate chloroquine, while an urticarial reaction from hydroxychloroquine would preclude use of chloroquine. Other side effects include nausea, headaches, myopathy, and bluish-gray hyperpigmentation of the skin. Lichen planus pigmentosus LPP is a rare form of lichen is characterized by oval or irregularly-shaped brown to gray-brown macules and patches on the skin. Areas that are exposed to sun such as the forehead, temples and neck are most commonly affe The incidence of hydroxychloroquine-related hyperpigmentation in patients with systemic lupus erythematosus is about 7%, but unlike hydroxychloroquine-related retinopathy, there is no clear association with cumulative dose or duration of use.1 Roughly half of cases occur in the first five years of treatment. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil hyperpigmentation Plaquenil Pigmentation - BJC Health, Lichen planus pigmentosus Genetic and Rare Diseases. Can plaquenil cause anemiaPlaquenil ibdNursing interventions prior to plaquenil administration Hydroxychloroquine Plaquenil and chloroquine cause ocular toxicity to various parts of the eye such as the cornea, ciliary body, and retina. Chloroquine can also induce cataract formation; however, no reports of hydroxychloroquine and cataract have been reported. This article focuses upon hydroxychloroquine retinopathy. Disease Hydroxychloroquine toxicity - EyeWiki. Hydroxychloroquine-related skin discoloration CMAJ. Hydroxychloroquine-induced Hyperpigmentation of the Skin.. Skin discoloration - bluish is found among people who take Plaquenil, especially for people who are female, 40-49 old, have been taking the drug for 2 - 5 years, also take medication Imuran, and have Epilepsy Hydroxychloroquine HCQ-associated hyperpigmentation is uncommon, with onset ranging from 3 months to 22 years following the initiation of therapy 1. A 32-year-old woman presented with a 1.5-year history of symmetric polyarthritis, positive rheumatoid factor, and anticyclic citrullinated peptide antibody, without erosive joint changes. Postinflammatory hyperpigmentation PIH has posed a substantial challenge for patients with higher Fitzpatrick skin types, specifically types III to VI. Treatment modalities pose a number of limitations due to the number of treatments required, potential side effects, and overall efficacy.