Chloroquine is now uncommonly used in favor of its derivative hydroxychloroquine. In the United States, hydroxychloroquine is most often used for its anti-inflammatory effects in rheumatology and dermatology. Hydroxychloroquine dose malaria Hydroxychloroquine for ra How does plaquenil affect sleep How much does aralen cost Fundus autofluorescence patterns in various stages of hydroxychloroquine retinopathy. Classic bull’s-eye maculopathy appearance A. As the RPE atrophies, the FAF intensity in the pericentral macula changes to a mottled, or speckled appearance B, and eventually coalesces into dark areas of absence of FAF signal once the cells have died C. The AAO published dosing and screening recommendations for chloroquine and hydroxychloroquine in 2016, revising previous recommendations published in 2011. The current maximum daily HCQ dose recommended by the AAO is 5 mg/kg of real weight. This is especially true in moderate and later stages of hydroxychloroquine maculopathy. 16 Researchers speculate as to the sensitivity of FAF in early stages of hydroxychloroquine toxicity for some patients, especially compared with spectral domain OCT and mfERG, and it is always important to check for toxic hydroxychloroquine dosing during your screening. 7 While early toxicity may be asymtomatic, patients with more advanced stage of toxicity may complain of color vision changes or paracentral scotomas. Its toxic effects on the retina are seen in the macula. Fundus autofluorescence in hydroxychloroquine toxicity FUNDUS AUTOFLUORESCENCE FINDINGS IN EARLY CHLOROQUINE., Despite Plaquenil dosing recommendations, retinal toxicity. Antimalarial hydroxychloroquineAralen pastillaPlaquenil sun allergyPlaquenil and daypro used together Plaquenil toxicity first affects small areas of the retina between 5° and 15° from the fovea. Figures 2 and 3 show three patients at different stages of toxicity. Figure 2 bottom right shows a color display of normal mfERGs. The amplitude of the mathematically derived b-wave of the mfERG is displayed in a color scale. Retina Today - Evaluating Hydroxychloroquine Toxicity With.. A Clinical Guide to Fundus Autofluorescence. The Nuts and Bolts of Fundus Autofluorescence Imaging.. New information shows that hydroxychloroquine retinal toxicity occurs 7.5 percent of the time, which is not that rare. 3 In those patients who are affected, their daily dose and duration of use varied widely. To report an unusual fundus autofluorescence aspect in a patient with suspected hydroxychloroquine retinal toxicity. Method Case report of an unusual presentation of a patient treated for 9 consecutive years with a therapeutically recommended dose of hydroxychloroquine. Jun 06, 2015 To report an unusual fundus autofluorescence aspect in a patient with suspected hydroxychloroquine retinal toxicity. Method Case report of an unusual presentation of a patient treated for 9 consecutive years with a therapeutically recommended dose of hydroxychloroquine.