I've stopped Sulfa as I was experiencing a bad taste & smell, which may be caused by sulfa. After a while it wasn't as effective and I too was prescribed methotrexate alongside. I'm about to start MTX & am hoping that I wont have side effects with that! The side effects of the methotrexate for me were horrendous (chronic chest infections) and I'm now asthmatic as a result. Plaquenil drug manufacturer Mefloquine hydrochloride chloroquine Hydroxychloroquine long half life Sulfasalazine also is available in an enteric-coated stomach-coated pill that helps prevent nausea and abdominal discomfort. Sun sensitivity of the skin can also be a a side effect. Those on sulfasalazine should use sunscreen SPF 15 or higher when outdoors and avoid prolonged exposure to sunlight. Plaquenil hydroxychloroquine and Azulfidine EN-tabs sulfasalazine delayed release tablets are used to treat rheumatoid arthritis. Plaquenil is also used to treat or prevent malaria, and to treat symptoms of discoid or systemic lupus erythematosus. Plaquenil is an arthritis medication and an anti infectious agent. Sulfasalazine is an arthritis medication and an IBD medication. There may be a negative interaction between Plaquenil and alcohol. There may be a negative interaction between Sulfasalazine and alcohol. I had side effects from MTX, which largely wore off, but haven't had any problems with the Hydroxy or Sulpha. I refuse to take it now even if its my passport to biologic treatment. I started with MTX which worked, but not enough so the others were added in which has been better. Sulfasalazine vs plaquenil Combination hydroxychloroquine and sulfasalazine - do., Plaquenil vs. Azulfidine Prescription Treatment for. Plaquenil and pregnancy riskChloroquine inhibit the novel heme polymerase enzymePlaquenil mg kg eyewikiChloroquine transfection what is SULFASALAZINE is for ulcerative colitis and certain types of rheumatoid arthritis. The lowest GoodRx price for the most common version of sulfasalazine DR is around $21.28, 59% off the average retail price of $52.37. What is Sulfasalazine DR? - GoodRx. Compare Plaquenil vs Sulfasalazine - Comprehensive.. Compare Sulfasalazine vs Plaquenil -. If the plaquenil is helping and they say you need it, I'd take it - the side effects will go away. I've not had experience with sulfasalazine - but from what I've read, the side effects of that med are about the same as those of plaquenil. BTW - sulfasalazine is an anti-inflammatory. Background/Purpose The combination of methotrexate MTX, sulfasalazine SSZ and hydroxychloroquine HCQ triple therapy is a highly effective and well-tolerated treatment in rheumatoid arthritis RA. While MTX is the cornerstone of most successful combination therapies, not all patients are candidates for, or tolerate, MTX. Hydroxychloroquine Plaquenil and sulfasalazine Azulfidine are used for mild rheumatoid arthritis. They are not as powerful as other disease-modifying antirheumatic drugs, but they usually cause fewer side effects.