Dark-skinned persons may experience generalized pruritus that is not indicative of drug allergy. Retinal toxicity that may occur with long-term high doses of chloroquine used in the treatment of other diseases is extremely unlikely with chloroquine given as a weekly malaria chemosuppressive agent. Plaquenil and celiac Plaquenil pregnancy class Chloroquine works best when you take it on a regular schedule. For example, if you are taking it once a week to prevent malaria, it is best to take it on the same day of each week. Make sure that you do not miss any doses. If you have any questions about this, check with your doctor. Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Because insufficient drug is excreted in breast milk to protect the infant, nursing infants should be given chloroquine. Chloroquine use is suitable for people of all ages and for pregnant women. Chloroquine method of action On the molecular mechanism of chloroquine's antimalarial action, CHLOROQUINE PHOSPHATE, USP Best price hydroxychloroquineWhat are the side effects of stopping plaquenilChloroquine chemoprophylaxisDrug of choice for chloroquine resistant malaria Chloroquine acts exclusively in the erythrocyte stage of malaria parasites. The antimalarial mechanism of action from chloroquine has not been fully elucidated. Many theories have been developed to elucidate the chloroquine mechanism of action, including DNA binding and inhibition of various enzymes and/or transporters. Chloroquine Modes of action of an undervalued drug.. Chloroquine Oral Uses, Side Effects, Interactions, Pictures.. Chloroquine - FDA prescribing information, side effects.. Chloroquine binds to heme or FP to form the FP-chloroquine complex; this complex is highly toxic to the cell and disrupts membrane function. Action of the toxic FP-chloroquine and FP results in cell lysis and ultimately parasite cell autodigestion. In essence, the parasite cell drowns in its own metabolic products. Apr 02, 2019 Mechanism of Action. Chloroquine is an antimalarial agent. While the drug can inhibit certain enzymes, its effect is believed to result, at least in part, from its interaction with DNA. However, the mechanism of plasmodicidal action of chloroquine is not completely certain. Activity in vitro and in vivo Chloroquine Phosphate. Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver.