Plaquenil fullfield erg severe

Discussion in 'Northwest Pharmacy' started by Alex7777, 10-Mar-2020.

  1. lux9r Well-Known Member

    Plaquenil fullfield erg severe


    It is generally well tolerated, but retinopathy is a concern. Retinopathy is rare, but is sight threatening, generally irreversible and may progress even after cessation of therapy. Although a number of risk factors have been proposed (such as duration of therapy and cumulative dose), the many exceptions (e.g.

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    Hydroxychloroquine is in a class of drugs called antimalarials. It is used to prevent and treat acute attacks of malaria. It is also used to treat discoid or systemic lupus erythematosus and rheumatoid arthritis in patients whose symptoms have not improved with other treatments. The electroretinogram ERG. The global or full-field electroretinogram ERG is a mass electrical response of the retina to photic stimulation. The ERG is a test used worldwide to assess the status of the retina in eye diseases in human patients and in laboratory animals used as models of retinal disease. It is clear that the corneal full-field flash ERG has no place for the testing of chloroquine or hydroxychloroquine retinal toxicity. It is not sensitive enough to pick up early focal maculopathies. In fact, almost all focal maculopathies have an either normal or near normal corneal full-field flash ERG.

    Novel technologies such as optical coherence tomography (OCT), fundus autofluorescence (FAF) and multifocal electroretinogram (mf ERG) may provide the earliest structural and functional evidence of toxicity in these stages. Retinopathy on low-dose HCQ, or no retinopathy after a very large cumulative dose of HCQ) highlight our limited understanding of the disease process.

    Plaquenil fullfield erg severe

    ERG and other discriminators between advanced., The Electroretinogram and Electro-oculogram Clinical Applications by.

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  6. Hydroxychloroquine should be used with extreme caution in patients with psoriasis or porphyria because it has been shown to precipitate severe attacks. Use hydroxychloroquine in patients with these conditions only if the potential benefit to the patient outweighs the possible risk.

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    In 2013, Roque published a review on “Chloroquine and Hydroxychloroquine Toxicity” which listed full-field ERG or electro-oculogram as one of the ancillary tests. 21 The article stated although not recommended for toxicity screening because of sensitivity, specificity and reliability issues, it may be used in diagnosing toxicity. Cein angiography, full-field ERG, and electro-oculogram are not considered to be helpful.1-3 mfERG is a sensitive, objective, and reproducible test for detecting hydroxy-chloroquine toxicity. Several drugs taken in high doses or for long periods of time can cause retinal degeneration with pigmentary changes. The full-field ERG Ganzfeld; ffERG measures the stimulation of the entire retina with a flashlight source under dark-adapted scotopic and light-adapted photopic types of retinal is useful in detecting disease with widespread generalized retinal dysfunction i.e. cancer associated retinopathy, toxic retinopathies, and cone.

     
  7. lesio XenForo Moderator

    Download PDF Many systemic medications may cause retinal toxicity. Quantitative assessment of outer retinal layers and. En Face OCT Imaging for the Diagnosis of Outer Retinal. Recommendations on Screening for Chloroquine and.
     
  8. Antonkomarov XenForo Moderator

    Cutting Pills in Half Could Pose Problems May 19, 2004 When researchers cut 10 mg tablets in an effort to produce two 5 mg pills, they ended up with dosages ranging anywhere from 2.5 mg to 7.5 mg.

    Tips for Cutting Back on Drinking
     
  9. grevunty Guest

    Hydroxychloroquine Plaquenil Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria.

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