Methotrexate is one of the most commonly used drugs to treat RA. However, it can decrease the levels of an important vitamin in your body called folate. Can i take ed pills with hydroxychloroquine used for Hydroxychloroquine mechanism rheumatoid arthritis Some patients complain of headache, fatigue, and feeling “wiped out” also called methotrexate “fog”. These side effects can often be overcome by increasing folic acid or using an activated form of folic acid known as folinic acid leukovorin® given as a 5mg dose 12 hours and sometimes 24 hours after methotrexate is given. Has anyone experienced any hair loss while on Methotrexate? I'm currently on 10mg once a week and have noticed an increase in hair loss. My doctor has also increased my folic acid dosage in hopes with helping it. I'm getting married in the fall and don't want to be bald by that day. Background 34 year old mother of 2 diagnosed in December with RA high RF and Anti-CCP. I'm on methotrexate injections just recently increased to 20 mg and plaquenil 200 mg twice a day. And folic acid. Early December I received a steroid injection to help with the pain/inflammation and improve my mobility temporarily. Your doctor may suggest you take a folic acid supplement, which is a manufactured form of folate. This leads to a side effect of methotrexate called folate deficiency. Methotrexate and folic acid and plaquenil for lupus Methotrexate vs Plaquenil Comparison -, Methotrexate and hair loss Lupus Forums at The Lupus Site Does hydroxychloroquine cause health problemsPlaquenil good reviews Imuran or methotrexate zmombomb I saw the Rheumy yesterday, and she was happy for me that Plaquenil is working on my pain, and upset that no other doctor had bothered to treat me with the Plaquenil in the past 9 years, then said that I will most likely need methotrexate or imuran, as I still have inflammation in my joints. Imuran or methotrexate - Lupus - MedHelp. Side effects plaquenil/methotrexate. rheumatoid. Compare Plaquenil vs Methotrexate -. Protocolled treatment of RA patients at both clinics consisted of MTX 25 mg/week reaching maximum dose within 4–8 weeks, preferably subcutaneously, and HCQ 400 mg/day as soon as feasible after diagnosis. Folic acid 10 mg/week is standard-prescribed to minimize MTX side effects. Methotrexate is a potent folic acid antagonist and so many doctors prescribe folic acid to help with the side effects of methotrexate, such as nausea. But she has MTHFR and folic acid is toxic for her, hence he switched her to the methylated version, L-5-Methylfolate. Side effects can develop if the methylfolate dose is too high. A weekly dose of methotrexate can cause unpleasant side effects, so Dooley recommends taking it when you have a couple of days off. For example, on Fridays, if you work during the week. “If you don’t feel 100 percent afterward, you have the weekend to get through it,” she says. It’s also important to avoid alcohol while taking methotrexate.