Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Hydroxychloroquine temporal arteritis Is plaquenil safe for pregnancy Chloroquine and receptor mediated endocytosis Hydroxychloroquine is also used for treating rheumatoid arthritis and systemic lupus erythematosus. Hydroxychloroquine sulfate is an anti-inflammatory via TNF, disease-modifying antirheumatic drug DMARD, and a heme polymerase inhibitor. It is used as a malaria treatment. The amount of hydroxychloroquine excreted in the urine as unchanged drug ranges from 6% to 60% median 23%, and 17% is excreted in the urine as metabolized drug. Twenty-four percent to 25% of hydroxychloroquine is excreted in feces, 5% is sloughed off in skin, and 45% is stored in lean tissues. Hydroxychloroquine sulfate tablets, USP are also indicated for the treatment of discoid and systemic lupus erythematosus, and rheumatoid arthritis. CONTRAINDICATIONS Use of this drug is contraindicated 1 in the presence of retinal or visual field changes attributable to any 4-aminoquinoline compound, 2 in patients with known hypersensitivity to 4-aminoquinoline compounds, and 3 for long-term therapy in children. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Hydroxychloroquine sulfate 2 Hydroxychloroquine Sulfate 200 mg, Hydroxychloroquine Information for Providers AIDSinfo Can plaquenil be used for sgroens syndrHydroxychloroquine muscle wastingChloroquine syrup dosage To treat malaria Hydroxychloroquine is usually given for 3 days, starting with one high dose followed by a smaller dose during the next 2 days in a row. Take this medicine for the full prescribed length of time for malaria. Plaquenil Hydroxychloroquine Side effects, Images, Uses.. Hydroxychloroquine Sulfate Tablets, USP 200 mg*. Hydroxychloroquine Oral Route Side Effects - Mayo Clinic. Based on PBPK models results, a loading dose of 400 mg twice daily of hydroxychloroquine sulfate given orally, followed by a maintenance dose of 200 mg given twice daily for 4 days is recommended for SARS-CoV-2 infection, as it reached three times the potency of chloroquine phosphate when given 500 mg twice daily 5 days in advance. In a case series, 13 mothers taking hydroxychloroquine sulfate 200 mg daily breastfed their infants for an average of 2.8 months range 1 to 6 months. None had evidence of retinal, motor or growth abnormalities during 12 months of follow-up. Hydroxychloroquine is sometimes given only once per week. Choose the same day each week to take this medicine if you are on a weekly dosing schedule. Take hydroxychloroquine with a meal or a glass of milk. To prevent malaria Start taking the medicine 2 weeks before entering an area where malaria is common. Continue taking the medicine regularly during your stay and for at least 8 weeks after you leave the area.