Hydroxychloroquine muscle toxicity

Discussion in 'Northwest Pharmacy Canada' started by expeditor, 08-Mar-2020.

  1. miqyokl New Member

    Hydroxychloroquine muscle toxicity


    It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc.

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    Cardiac toxicity is an under‐recognized adverse effect of CQ/HCQ leading to cardiomyopathy with concentric hypertrophy and conduction abnormalities, with the potential for significant morbidity and mortality. Hydroxychloroquine is in a class of drugs called antimalarials. It is used to prevent and treat acute attacks of malaria. It is also used to treat discoid or systemic lupus erythematosus and rheumatoid arthritis in patients whose symptoms have not improved with other treatments. Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more.

    For prolonged treatment of lupus or arthritis, adverse effects include the acute symptoms, plus altered eye pigmentation, acne, anaemia, bleaching of hair, blisters in mouth and eyes, blood disorders, convulsions, vision difficulties, diminished reflexes, emotional changes, excessive coloring of the skin, hearing loss, hives, itching, liver problems or liver failure, loss of hair, muscle paralysis, weakness or atrophy, nightmares, psoriasis, reading difficulties, tinnitus, skin inflammation and scaling, skin rash, vertigo, weight loss, and occasionally urinary incontinence. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. For short-term treatment of acute malaria, adverse effects can include abdominal cramps, diarrhea, heart problems, reduced appetite, headache, nausea and vomiting.

    Hydroxychloroquine muscle toxicity

    Drug-related Myopathies of Which the Clinician Should Be Aware, Hydroxychloroquine MedlinePlus Drug Information

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  6. Side effects include irritability, headache, weakness, hair lightening or loss, stomach upset, nausea, dizziness, muscle pain, rash and itching. Rarely, hydroxychloroquine can affect the bone marrow leading to reduced white blood cells leukopenia or platelets thrombocytopenia and abnormal red blood cells. Rare but potentially serious eye toxicity can occur.

    • Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria.
    • Hydroxychloroquine Plaquenil Side Effects & Dosage for..
    • Hydroxychloroquine-Induced Myopathy Request PDF.

    This article is from June 2011 and may contain outdated material. Download PDF. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. Hydroxychloroquine and colchicine neuromuscular toxicity is well documented. The largest literature review on colchicine myopathy was conducted by Wilbur and Makowsky in 2004 where a database search found 75 cases. Most patients presented with proximal muscle weakness. A wide range of treatment durations were noted from 4 days to 11 yrs with cumulative daily doses of 1.4 ± 0.96 mg. The. Hydroxychloroquine typically is very well tolerated. Serious side effects are rare. The most common side effects are nausea and diarrhea, which often improve with time. Less common side effects include rash, changes in skin pigment such as darkening or dark spots, hair changes, and muscle weakness.

     
  7. Glob Well-Known Member

    Hydroxychloroquine is a disease-modifying anti-rheumatic drug (DMARD). Hydroxychloroquine Side-effects, uses, time to work Hydroxychloroquine Plaquenil Side Effects & Dosage for. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses
     
  8. Shtirlits New Member

    What is Macular Degeneration? - AMDF Macular Degeneration. Macular Degeneration is the leading cause of vision loss, affecting more than 10 million Americans – more than cataracts and glaucoma combined. At present, Macular Degeneration is considered an incurable eye disease. Macular Degeneration is caused by the deterioration of the central portion of the retina.

    The Risk of Retinal Toxicity with Plaquenil