Chloroquine resistance in plasmodium falciparum

Discussion in 'Northwest Pharmacy Canada' started by ivvi, 16-Mar-2020.

  1. jbounce New Member

    Chloroquine resistance in plasmodium falciparum


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

    Chloroquine interaction Plaquenil malaria prophylaxis Chloroquine po 300 mg daily prophylaxis Take hydroxychloroquine with neurontin

    A distinct genotype designated Dd2-type profile consisting of 12 point mutations and 3 repetitive regions of the CG2 gene, a candidate gene for chloroquine resistance, has been associated with in vitro resistance in laboratory-adapted strains of Plasmodium falciparum. The DNA sequence of clinical isolates, characterized by in vitro and in vivo tests, was analyzed to evaluate whether the genotype corresponds to the phenotype in naturally occurring parasites. Development of Chloroquine Resistance in Plasmodium falciparum Drug resistance is the ability of a parasite to survive despite the presence of a drug that is meant to kill it in toxic levels. Resistance developed by most parasites that were initially sensitive to drugs mostly result from mutations in the genes responsive to the drug. Chloroquine-resistant P. falciparum first developed independently in three to four areas in Southeast Asia, Oceania, and South America in the late 1950s and early 1960s. Since then, chloroquine resistance has spread to nearly all areas of the world where falciparum malaria is transmitted.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine resistance in plasmodium falciparum

    CRT - Chloroquine resistance transporter - Plasmodium falciparum - CRT., Chloroquine Resistance in Plasmodium falciparum - microbewiki

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    • Drug resistance in malaria - World Health Organization.
    • Drug Resistance in the Malaria-Endemic World - CDC.
    • Lack of Evidence for Chloroquine-Resistant Plasmodium..

    The first confirmed cases of chloroquine-resistant Plasmodium falciparum acquired in Africa were reported in 1978 1 and occurred in non-immune travelers who had been in East Africa for relatively short periods of time. In in-vitro tests 7 of 10 70% isolates were chloroquine-resistant. Introduction THE presence of chloroquine-resistant Plasmodium falciparum in Africa was first described in 1978 in non-immune travellers who acquired the infection in Kenya and Tanzania. Chloroquine-resistant Plasmodium falciparum accumulate significantly less chloroquine than susceptible parasites, and this is thought to be the basis of their resistance. However, the reason for the lower accumulation of chloroquine was unknown. The resistant parasite has now been found to release chloroquine 40 to 50 times more rapidly than the susceptible parasite, although their initial.

     
  7. anlimit XenForo Moderator

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  9. Fenard New Member

    Hydroxychloroquine Side Effects, Dosage, Uses, and More Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It’s also used to prevent and treat malaria. How it works. Hydroxychloroquine is an antimalarial drug.

    Drug tapering An option, not a necessity, for patients with.