Most importantly, you help support continued development of this site. The majority of cases of retinotoxicity have occurred in patients that have had a cumulative dose exceeding 1000g of hydroxychloriquine (Plaquenil). This level is reached in about 7 years with the most common daily dose of Plaquenil, 400 mg/day (200 bid). Hydroxychloroquine muscle toxicity Natural substitute for chloroquine Yesterday, he told me that there is some damage to the retina in one of my eyes. that the last three tests have had the exact results. He told me that the plaquenil stays in your system. it is not metabolized by the liver. Therefore, the damage is irreversible. He also told me that the damage can continue even after you stop taking the plaquenil. Hydroxychloroquine, sold under the brand name Plaquenil Sanofi-Aventis, is an antimalarial drug that has gained widespread use in treating various autoimmune diseases, including systemic lupus erythematosus and rheumatoid arthritis. 1 By some estimates, more than 150,000 patients are on long-term therapy with this medication in America alone. 2 Retinal toxicity associated with HCQ use is. Retinal Damage. According to Drugs.com, Plaquenil given for a long term can cause retinal disorders after a few months or years of daily use--especially if the dose exceeds 400mg per day. The risk of retinal damage increases at doses of 600mg to 700mg. It now solely uses real body weight (rather than ideal body weight) based on new recommendations from a 2014 study (1). Disclaimer: This tool is designed to help eye care professionals better understand the risk the of retinotoxicity from hydroxychloroquine. Please note: This calculator was modified in 9/2015. Plaquenil retinal damage Hydroxychloroquine Retinopathy Still Alive and Well - The., Multimodal Imaging in Plaquenil Toxicity Hydroxychloroquine use during pregnancySilver and chloroquineArtemisinin-based combination therapy chloroquineIndocin and plaquenilHydroxychloroquine how it works Plaquenil is manufactured in only a 200 mg tablet The typical dosage is either 200 or 400 mg per day 200 mg daily puts anyone under 68 pounds at risk1 400 mg of Plaquenil daily puts anyone under 135 pounds at a higher risk for toxicity Therefore, 200mg of Plaquenil daily is going to be a safe dosage for virtually all adults13 Early Plaquenil Toxicity Detected without Bull’s Eye Maculopathy. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis. Protecting your eyesight when taking Plaquenil Lupus.. She claimed my husband's eye condition was due to his age, and not Hydroxychloroquine, of which retinal damage is a well-known side effect. My husband has continued to get more flashes and floaters. His right eye is pretty useless now. According to Drugs.com, Plaquenil given for a long term can cause retinal disorders after a few months or years of daily use--especially if the dose exceeds 400mg per day. The risk of retinal damage increases at doses of 600mg to 700mg. While side effects of corticosteroids are usually to blame, there is also the possibility of ocular damage associated with long-term use of the antimalarial drugs hydroxychloroquine brand name Plaquenil® and chloroquine. Improved vision screening tests and updated dosing guidelines are key to avoiding such complications.