I also have been having unexplained swelling of my tongue, wrists, bottom of my feet and lip, spreading up in my cheek. Now my wife and i are very concerned and planning on going to see my doctor soon. I know it isn't allergies because I have kept a diary and there is no pattern as in your case I too would like some help in clarifying it. Hydroxychloroquine hydroxyzine interaxtion Can chloroquine abort Lip and eye periorbital swelling are the most common. Swelling of the tongue, pharynx, and larynx is particularly problematic. Fatalities can occur because of laryngeal edema, but pharyngeal edema and tongue swelling can be similarly disastrous if they are massive. Get emergency medical help if you have signs of an allergic reaction to Plaquenil hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Taking Plaquenil long-term or at high doses may cause irreversible damage to the retina of your eye. Stop taking Plaquenil and call your doctor at once if you have trouble focusing, if you see light streaks or flashes in your vision, or if you notice any swelling or color changes in your eyes. Call your doctor at once if you have Usually not Chapped lips is often due to lip eczema dryness, irritation, cracking, peeling. Too much sun, wind, or water exposure; excessive washing; repeated lip licking; and allergies to lip balm or lipstick ingredients are common causes. Allergic reactions hives, etc. can chap lips. I have tried to put all of this on food, detergent, allergies, etc.. Currently as I'm writing this am having the same symptoms you describe under my feet, it started about 4-5 months ago, were swelling of the lips, tongue and side of the mouth swells up, and most recently started to get the swelling under my feet with the same description you noted, also my hand and my wrist, all these caused an itching feeling and felt very warm to touch and is difficult to walk on. I ate a chocolate apricot cake, something I have never had. The same exact thing that you have described has happened to me and much more regularly recently. my wife and i thought it maybe caused due to an allergic reaction, i did go to en allergist and after various tests he indicated that i am not allergic to anything. My foot had this crazy itch (left foot) and then I was walking and it felt like the outside of my foot had like gum or something stuck to the bottom of it. I have been told it is stress, but I don't feel stressed. Plaquenil lip swelling Mouth Sores and Lupus - Kaleidoscope Fighting Lupus, Plaquenil Uses, Dosage & Side Effects - Antimalarial resistance chloroquineWhat is plaquenilCan i take plaquenil for discoid lupus flareChloroquine phosphate shelf life Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as. Plaquenil Hydroxychloroquine - Side Effects, Dosage, Interactions - Drugs. Lupus symptoms chapped lips - What Does the Doctor Say?. Lip swelling in Systemic lupus erythematosus - eHealthMe. Plaquenil Hydroxychloroquine belongs to a group of medications known as anti-inflammatories and antimalarials. It is used alone or in combination with other anti-arthritic medications to treat rheumatoid arthritis. It helps to reduce pain, stiffness, and swelling in joints. What are the possible side effects of hydroxychloroquine Plaquenil, Plaquenil Sulfate, Quineprox? Get emergency medical help if you have signs of an allergic reaction hives; difficulty breathing; swelling of your face, lips, tongue, or throat. It actually wasn't a sore or ulcer at all, but a cyst or mucocele cause by a blockage of minor salivary glands in my lip. The salivary glands are involved in the inflammatory process of Sjogren's syndrome, which is why many of us with Sjogren's have dry mouths and sometimes painful and enlarged salivary glands.