Chloroquine mechanism of action

Discussion in 'International Pharmacy' started by Lagas, 28-Feb-2020.

  1. Valerochka User

    Chloroquine mechanism of action


    It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc.

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    This finding, obtained without making any assumption on the nature of PfCRT, implies that hypothesis H2 is plausible, regardless of the chloroquine species involved in the chloroquineHM binding and of the mechanism of action of the mutated PfCRT. Consequently, none of the 20 cells C 1–5,1–4 can be shaded at this stage. The clinical usefulness of chloroquine, and in some recent cases of quinine as well, has been much reduced by the evolution and spread of chloroquine resistant malaria parasites. The mechanism of resistance involves a reduced accumulation of the drug, although again the mechanism involved is controversial. Its mechanism of action is unknown; however, malarial parasites invade human red blood cells, and chloroquine may prevent malarial parasites from breaking down metabolizing hemoglobin in human red blood cells.

    The most serious adverse effects affect the eye, with dose-related retinopathy as a concern even after hydroxychloroquine use is discontinued. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea.

    Chloroquine mechanism of action

    Chloroquine - Wikipedia, Chloroquine Mechanism of drug action and resistance in.

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  3. Oct 01, 2018 Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. It can also inhibit certain enzymes by its interaction with DNA.

    • Chloroquine - FDA prescribing information, side effects and uses.
    • Aralen chloroquine Malaria Drug Side Effects & Dosage.
    • PDF Malaria Mode of action of chloroquine and mechanism of..

    Chloroquine resistance is associated with a decrease in the amount of chloroquine that accumulates in the food vacuole, the site of action for chloroquine. The mechanism for this decreased accumulation is controversial. Some studies have shown that the decrease in drug accumulation is due to an increase in drug efflux. Abstract. Chloroquine is thought to exert its antimalarial effect by preventing the polymerization of toxic heme released during proteolysis of hemoglobin in the Plasmodium digestive vacuole. The mechanism of this blockade has not been established. We incubated cultured parasites with subinhibitory doses of 3Hchloroquine and 3H quinidine. Apr 02, 2019 Mechanism of Action Chloroquine is an antimalarial agent. While the drug can inhibit certain enzymes, its effect is believed to result, at least in part, from its interaction with DNA.

     
  4. DrCoolMov User

    Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine (the active ingredient contained in Plaquenil) may cause some unwanted effects. Hydroxychloroquine Reviews Everyday Health Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Plaquenil and weight gain?
     
  5. s0laris Moderator

    AZATHIOPRINE and Lupus - Kaleidoscope Fighting Lupus Azathioprine Imuran is an immunosuppressant medication. These types of medications work by inhibiting or suppressing activity in the immune system. Unfortunately, with most autoimmune disorders, the immune system is overactive, producing an abundance antibodies that attack cells and cause inflammation.

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  6. RSA New Member

    Plaquenil Coupons, Cost Comparison, Discount Card Plaquenil is a member of a family of drugs called antimalarials – as the name implies, it's used to prevent or treat malaria, a serious, mosquito-borne tropical illness. People traveling to South America, South Asia and Africa would be wise to get a prescription for this medication.

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