Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Plaquenil for lupus nephritis Undifferentiated connective tissue disease and plaquenil Chloroquine pregnancy One of the most significant side effects of the drug is its possibility of causing eye problems resulting in blurred or decreased vision. The most common issue is damage to the retina. It can impair your color vision or damage the retinal cells particularly in the area right around the central vision. Chloroquine Ocular Side Effects. Chloroquine is especially absorbed by the pigment cells in the eye. Eye side effects are serious and can result in loss of vision. The side effects may occur at anytime. The higher the dose and the longer the time of use makes it more likely to occur. Initially retinal toxicity due to long-term use of chloroquine Aralen for malaria was reported in 1959 by Hobbs et al. 106 Currently, hydroxychloroquine sulphate Plaquenil is the quinoline agent of choice for the treatment of autoimmune diseases with a far lower incidence of adverse reactions. 107, 108 Hydroxychloroquine has been associated with many ocular toxic effects including keratopathy, ciliary body dysfunction, lens opacities, outer retinal damage, and pigmentary retinopathy. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Plaquenil ocular side effects Plaquenil Hydroxychloroquine - Side Effects, Dosage., Chloroquine or Hydroxychloroquine Plaquenil and the. Plaquenil pregnancy drug classChloroquine and neuropathyCan plaquenil cause eye pain Chloroquine and hydroxychloroquine both belong to the quinolone family and share similar clinical indications and side effects, including retinal toxicity. Chloroquine-induced retinal toxicity was first described in 1959 and the retinal toxic effects of hydroxychloroquine were later described in 1967 3, 4. Hydroxychloroquine Plaquenil Toxicity and.. Ocular side effects of anti-rheumatic medications what a.. Rx Side Effects New Plaquenil Guidelines and More.. Ocular Surgery News. And of greater importance, Plaquenil has less systemic side effects than other drugs used for lupus, so there is a real advantage in using it as long as one can. You want a. Protecting your eyesight when taking Plaquenil. With all of the physical and emotional complications that lupus can cause, it’s easy to overlook symptoms that seem minor at first. But take this advice Don’t ignore changes in vision. For the Consumer. Continuing ringing or buzzing or other unexplained noise in the ears. feeling of constant movement of self or surroundings. irritability. nausea. nervousness. nightmares. sensation of spinning. shakiness and unsteady walk. uncontrolled eye movements. unsteadiness, trembling, or.