So far I have no more energy than when I first started and has developed neuropathy which I have just found out from Web MD that this neuropathy is one of the side effects of this med! Saying that by stopping this it would take another 6 months to build up the benefit. There are other meds that can help with what you are experiencing, and if your doctor didn't address that then I would seek out a second opinion... Please don't stop your plaquenil until you are sure it is the right thing to do and in your best interest. Con que puedo tomar el plaquenil para no engodar Plaquenil sleepy I say this because Plaquenil has a chemical half-life of 30-60 days you can confirm this on wiki or RX info on the drug--so it takes a LONG time to get out of your system.long for you to notice changes in days. If you remember, most wait at least 3 months before they even see any improvement. Sometimes what is suggested no antacid for 4 hours is not necessarily required if it means you can't or don't want to take your plaquenil anymore. The worry is. the antacid will affect the absorption of the plaquenil and the amount your body can absorb. With the Plaquenil I don't think you will find much relief in such a short time on it & at half of a workable dose. I have read about people stopping P & flaring up. Those who stopped it abruptly had real problems similar to what you are experiencing. If you really need to get off it, I would taper down slowly, very slowly. Plaquenil is a 6-weeker as far as the benefits are concerned, but it would be more dangerous to stop if you spend a lot of time outside and if this were the summer. Or maybe another doctor if you're not comfortable w/your current one. Can you break plaquenil in half Mycophenolate mofetil with Plaquenil Mayo Clinic Connect, Plaquenil and heartburn rheumatoid Chloroquine pretreatment degradation toxicityPlaquenil how does it workPlaquenil 200 mg precio colombiaPlaquenil and heartUsing pei vs chloroquine SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Hydroxychloroquine plaquenil withdrawl? - LUPUS UK. Plaquenil hydroxychloroquine 200mg is it causing itchy.. Plaquenil is a 6-weeker as far as the benefits are concerned, but it would be more dangerous to stop if you spend a lot of time outside and if this were the summer. If you're gonna experiment, I went off it cold turkey as it didn't hurt to do it that way, but you better get back on before the summer or you could experience a flare-up. Overall Plaquenil did take away the muscle and joint pain. It worked wonders for that. For that reason I am satisfied with plaquenil for what I took it for. Took about 5-6 months to see full effect. Since reducing the dose from 400mg to 200mg 4 months ago I do feel some of this pain returning You win some, you lose some! M 49 1 years 400mg day Following a single 200 mg oral dose of PLAQUENIL to healthy males, the mean peak blood concentration of hydroxychloroquine was 129.6 ng/mL, reached in 3.26 hours with a half-life of 537 hours 22.4 days. In the same study, the plasma peak concentration was.