The association between HCQ use and pregnancy outcomes (early spontaneous abortion, fetal death, and preterm and term live birth) was analyzed using generalized estimating equations (GEE) accounting for the occurrence of multiple pregnancies per patient. Analyses were adjusted for antiphospholipid antibody (a PL) status. 110 pregnancies (63 mostly Caucasian patients) were included, of which, in 30, HCQ was used; overall occurrence of flares was low (non-HCQ group: 5 mild (6.4%) and 2 severe (2.6%); HCQ group: 2 mild (6.7%) and no severe flares). Hydroxychloroquine issues Improvement of ra with hydroxychloroquine Hair loss and plaquenil Is plaquenil porcine based Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Plaquenil hydroxychloroquine has a good safety record in lupus pregnancy, and is usually continued if needed to control maternal lupus. Management and Monitoring Lupus pregnancy should be timed to coincide with a period of good disease control if at all possible. Technically, Plaquenil does not have an official pregnancy Category rating, as is common with older medications. However, most sources consider it to be a pregnancy Category C medication. In animal studies, it was shown that Plaquenil crosses the placenta and accumulates in the eyes of. Apart from disease flares during pregnancy, SLE patients have an increased risk of intrauterine growth restriction (OR 2.6), (pre)eclampsia (OR 3.0), and preterm birth (OR 2.4) compared to the healthy population . The HCQ group showed a trend towards lower dosage of prednisone (OR 0.2 (95% CI 0.0–1.4); Pregnancy constitutes a challenge in patients with systemic lupus erythematosus (SLE). Is plaquenil safe for pregnancy Plaquenil during pregnancy? lupus, Lupus and Pregnancy Johns Hopkins Lupus Center Hydroxychloroquine brands HCQ use was associated with longer pregnancy duration in the vulnerable preterm birth population, underscoring the beneficial effect of HCQ use during pregnancy. iObjective/i. To investigate the effect of hydroxychloroquine HCQ in pregnant women with systemic lupus erythematosus SLE. iMethods/i. Hydroxychloroquine Use in Lupus Patients during Pregnancy.. Plaquenil and Pregnancy - Antibiotics Home Page. Hydroxychloroquine 'Probably Safe' in Pregnancy MDedge ObGyn. Hydroxychloroquine Pregnancy Warnings Animal studies have revealed evidence of fetal harm. Use of chloroquine and other 4-aminoquinolines in high doses and for prolonged durations has been associated with neurological disturbances and interference with hearing, balance, and vision in the fetus. Hydroxychloroquine Plaquenil is recommended for all women with lupus during pregnancy. Hydroxychloroquine was originally an antimalarial medication that was found to reduce the risk of lupus flares during pregnancy as well. It isn't known to cause any problems in babies and may help prevent neonatal lupus. Sunday, 01 July 2018. In every pregnancy, a woman starts out with a 3-5% chance of having a baby with a birth defect. This is called her background risk. This sheet talks about whether exposure to hydroxychloroquine may increase the risk for birth defects over that background risk.