Because polymyalgia rheumatica does not often cause swollen joints, it may be hard to recognize. It may occur with another health problem, giant cell arteritis. Chloroquine eea1 Hydroxychloroquine vision side effects The group recognised that no recommendation can be made for the use of other non-biologic ie, conventional synthetic and conventional targeted DMARDs in PMR because of the lack of good evidence from PMR studies. Hydroxychloroquine was investigated by a single very low QoE retrospective study reporting no benefit regarding relapse rate.51 The antimalarial agents chloroquine and hydroxychloroquine have been used widely for the treatment of rheumatoid arthritis and systemic lupus erythematosus. These compounds lead to improvement of clinical and laboratory parameters, but their slow onset of action distinguishes them from glucocorticoids and nonsteroidal antiinflammatory agents. I have Polymyalgia Rheumatica PMR, an autoimmune disease similar to rheumatoid arthritis. Polymyalgia is a muscle inflammation disorder that causes muscle pain and stiffness in your neck, shoulders, and hips. It is most common in women and usually occurs in people over 60. The main symptom is stiffness after resting. The disease affects women somewhat more often than men. The average age when symptoms start is 70, so people who have PMR may be in their 80s or even older. Hydroxychloroquine pmr Hydroxychloroquine Plaquenil, Mechanism of action of hydroxychloroquine as an antirheumatic. Aralen and water PMR in most patients evolved into seronegative RA, which was dramatically responsive to HCQ use. Treatment of acute PMR with HCQ was a rational alternative to CS use even if progressive additive synovitis had not yet occurred. HCQ versus Cs for PMR I came across this. - PMRGCAuk. Life with Polymyalgia Rheumatica -. Hydroxychloroquine Oral Uses, Side Effects, Interactions.. Apr 01, 2016 The diagnostic diversity of polymyalgia rheumatica PMR can easily be obscured by the widespread use of corticosteroids CSs early in the disease course. This study observed the course of PMR without CSs and determined whether alternative medication could be useful. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of hydroxychloroquine in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving this medicine. Side Effects. Drug information provided by IBM Micromedex Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.