There are hundreds of drugs with potential retinal toxicity—so many that the National Registry of Drug-Induced Ocular Side Effects doesn’t stratify them by incidence or effect, said Frederick W. “Rick” Fraunfelder, MD, director of the Registry and associate professor of ophthalmology at Oregon Health & Science University in Portland. Plaquenil premaculopathy Hydroxychloroquine for frontal fibrosing alopecia Chloroquine and hydroxychloroquine for cancer therapy How to Succeed in Plaquenil Screenings The spectrum of OCT findings associated with the medication can make incorporating the 2016 guidelines harder than you think. Here’s help. By Marlon Demeritt, OD, Sherrol Reynolds, OD, Diana Shechtman, OD, and Jennifer Davidson, OD Abstract. Background The American Academy of Ophthalmology recommendations on screening for chloroquine CQ and hydroxychloroquine HCQ retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. In 2002, the American Academy of Ophthalmology AAO established ocular examination guidelines for screening patients on Plaquenil therapy. Testing included a comprehensive eye exam that consisted of an assessment of the posterior segment with careful evaluation of associated macular changes or signs of retinal disease. 4 Baseline fundus. “It’s a pretty rare thing.” Nevertheless, he urged doctors to master the Academy’s new guidelines, because the effects from chloroquine and hydroxychloroquine, when they do occur, are severe and often irreversible. “Plaquenil toxicity isn’t even in the top 10, or the top 100” if you’re looking at incidence, he said. Aao 2016 plaquenil guidelines Plaquenil Guidelines Point Out New Risks, New Presentation., Recommendations on Screening for Chloroquine and Hydroxychloroquine. Chloroquine fda pregnancy categoryHydroxychloroquine 200 mgtaLupus hydroxychloroquine sulfate Plaquenil toxicity screening has new guidelines that were updated in 2016. This is an update for your information if you have more questions about specific cases or need an mfERG for a patient, don’t hesitate to contact me. PowerPoint. Update on Plaquenil Testing. New Plaquenil Guidelines -. Preferred Practice Pattern® Guidelines - American Academy of Ophthalmology. The AAO 2016 guidance suggested that the rates of HCQ retinopathy were higher than had previously been recognised.1 The recommended dosage per the AAO 2016 guidelines was calculated for the 2696 patients who provided their body weight, and compared with their actual, current HCQ dose. Twenty-six per cent of the patients were on doses exceeding. The American Academy of Ophthalmology has published several dosing and screening recommendations for hydroxychloroquine to avoid potential retinal toxicity, yet some patients still experience. The revised screening guidelines recently released by the AAO are a bit more rigorous than those previously advocated, as they call for the use of newer, potentially more sensitive imaging modalities. By following these guidelines, and by maintaining a high index of suspicion, most cases of severe toxicity may be prevented.