For the last seven months I have been on Prednisone up to 60 mg a day and Imuran 150 mg a day. Needless to say not only did neither drug work to bring my platelets up or suppress my Lupus, I suffered with every side effect almost in the book. Does hydroxychloroquine decrease human anti-chimeric antibody Plaquenil pmr Hi, I am a 53 year old female and was diagnosed with Lupus and had a low blood platelet count in January 2012. For the last seven months I have been on Prednisone up to 60 mg a day and Imuran 150 mg a day. If moderate or high disease activity exists after 3 months of combination DMARDs, an option is to add or switch DMARDs and reassess in another 3 months. For patients with low disease activity without poor prognostic features who have moderate or high disease activity after 3 months of DMARD monotherapy, the addition of methotrexate is an option. Platelets, or thrombocytes, are cells that are vital to your blood's ability to clot. While a low platelet count, or thrombocytopenia, can arise from a variety of conditions, a variety of vitamin supplements can help prevent and treat this condition. My hematologist also was very wary of the side effects and I am now off the Imuran and my Prednisone is down to 15 mg a day with less of the drug side effects. My first RA and I parted ways in July after he kept wanting to increase the doses of the medications even though I was getting high liver enzyme and bilirubin levels due to the drugs. Plaquenil lowef platelets Low WBC/RBC and starting plaquenil? - Sjogren's World, Plaquenil hydroxychloroquine sulfate dose, indications. Cheapest brand plaquenil PLAQUENIL is used concomitantly with other arrhythmogenic drugs. Mefloquine and other drugs known to lower the convulsive threshold PLAQUENIL can lower the convulsive threshold. Co-administration of PLAQUENIL with other antimalarials known to lower the convulsion threshold e.g. mefloquine may increase the risk of convulsions. PLAQUENIL HYDROXYCHLOROQUINE SULFATE TABLETS, USP DESCRIPTION. Are There Vitamins That Can Raise Platelets?. Platelets plaquenil Anti-Inflammatories discussions.. A complete blood count CBC is the most commonly performed lab test in the U. S. and is used to analyze red blood cells RBCs, white blood cells WBCs, and platelets. Many people with systemic lupus have abnormal CBCs. White blood cell counts can be low leukopenia due to lupus, immunosuppressive therapy, or the presence of a virus. Doctors give trusted answers on uses, effects, side-effects, and cautions Dr. Dugan on plaquenil and low wbc This drug can effect the bone marrow and make the white blood count and platelets low. Your doctor may want to stop this medication, but don't stop it till you talk to the doctor. Good luck! Plaquenil and Thrombocytopenia - from FDA reports Summary Thrombocytopenia is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years, also take medication Enbrel, and have High blood pressure.