I can say that I am not having pain like I used to, and I am so grateful for that! I don't know if this is just the RA in full swing, or if it is a side effect of the Plaquenil. I have been running a low-grade fever (around 99.8) for about a week and a half now. Plaquenil cause fatigue Plaquenil congestive heart failure Hydroxychloroquine keratopathy Is plaquenil with methocarbamol 500 mg Hydroxychloroquine is the immunomodulatory drug most frequently used for primary Sjögren syndrome, 7 usually prescribed for patients with fatigue, arthralgia, and myalgia 8-10 rather than severe systemic manifestations. The latter symptoms are treated with corticosteroids and azathioprine, cyclophosphamide, mycophenolate mofetil, or rituximab. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. I've been on Plaquenil now for three months and its starting to help with the pain although I have diarrhoea every day but it's manageable. But I'm really struggling with fatigue now - worse than its ever been. Don't know whether its the RA itself or my body reacting to Plaquenil but I can't seem to do anything without being really really tired. My normal body temperature is low, around 97.5, so I don't know if 99.8 would be considered a fever. It comes & goes and I can tell when it is up because I feel hot. Plaquenil et fatigue Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria, Hydroxychloroquine Plaquenil Low cost hydroxychloroquineDo side effects of plaquenil start right away D'autres effets secondaires Plaquenil parfois associés à une thérapie à long terme incluent l'acné, les changements dans les cheveux et la couleur de la peau, la diarrhée, les changements émotionnels, fatigue, aphtes, nausées, perte de poids et des convulsions. Le traitement du paludisme Plaquenil Effets secondaires oculaires - Terre-. Is extreme fatigue a side effect of Plaquenil - NRAS. Hydroxychloroquine User Reviews for Rheumatoid Arthritis at. May 05, 2010 Hi everyone, I have fibro and RS and Sjoegren's. I have been on Plaquenil for a little over 2 months now. I can say that I am not having pain like I used to, and I am so grateful for that! The problem now is the undending fatigue! I don't know if this is just the RA in full swing, or if it is a side effect of the Plaquenil. PDR Drug Summaries are concise point-of-care prescribing, dosing and administering information to help phsyicans more efficiently and accurately prescribe in their practice PDR's drug summaries are available free of charge and serve as a great resource for US based MDs, DOs, NPs and PAs in patient practice Plaquenil and Fatigue - from FDA reports Summary Fatigue is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years, also take medication Enbrel, and have Pain.