Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Hydroxychloroquine pill Chloroquine and immune complement activation Does Plaquenil Interact with other Medications? Severe Interactions. These medications are not usually taken together. Consult your healthcare professional e.g. doctor or pharmacist for more in. She said that plaquenil was the least likely to cause liver issues. I did read that there is a small possibility that was maybe the brand. Has anyone had a reaction to the generic, but then did ok with the name brand Plaquenil? Or anyone else that had such a severe reaction to Hydroxycloroquine but did well with another med entirely? Plaquenil side effects. Get emergency medical help if you have signs of an allergic reaction to Plaquenil hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Taking Plaquenil long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Reactions to plaquenil Plaquenil Oral Uses, Side Effects, Interactions., Allergic reaction to Plaquenil Lupus Forums at The Lupus Site Prices for plaquenil Plaquenil Adverse Reactions with Treating Lupus and Rheumatoid Arthritis Ocular Reactions The goal with ocular screening for the side effects of Plaquenil is to find the damage at the earliest stage to reduce the amount of vision loss. Plaquenil Hydroxychloroquine Side Effects and Adverse Reactions. Plaquenil Uses, Dosage & Side Effects -. Plaquenil Indications, Side Effects, Warnings -. If common side effects do occur, they are usually minor and last only for a short period of time. Please note the rare side effects listed below, specifically retinopathy, which causes damage to the eyes. Side effects associated with Plaquenil are placed in three categories common, less common, and rare. Plaquenil received an overall rating of 5 out of 10 stars from 4 reviews. See what others have said about Plaquenil, including the effectiveness, ease of use and side effects. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria.