It regulates the activity of the immune system, which may be overactive in some conditions. Hydroxychloroquine can modify the underlying disease process, rather than simply treating the symptoms. Plaquenil and oxycodone Chloroquine gametocidal Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as. Hydroxychloroquine may inhibit P-glycoprotein P-gp. Digoxin is a substrate for P-gp transport. For patients on a stable digoxin regimen and initiating hydroxychloroquine, no initial dose adjustment of either drug has been advised; however, serum digoxin concentrations should be monitored and used for digoxin dose titration as clinically. Weight based dosage in adults and pediatric patients 13 mg/kg 10 mg/kg base, not to exceed 800 mg 620 mg base followed by 6.5 mg/kg 5 mg/kg base, not to exceed 400 mg 310 mg base, at 6 hours, 24 hours and 48 hours after the initial dose. PLAQUENIL film-coated tablets cannot be divided, therefore they should not be used to treat patients who weigh less than 31 kg. Hydroxychloroquine is often taken in combination with other drugs such as methotrexate. Over the long term hydroxychloroquine can reduce pain, swelling and joint stiffness. It may be as long as 12 weeks before you notice the benefits. Plaquenil dose for arthritis Hydroxychloroquine User Reviews for Rheumatoid Arthritis., Plaquenil hydroxychloroquine sulfate dose, indications. Hydroxychloroquine 200mg acetaminophen 400mgChloroquine phosphate molecular weight Hydroxychloroquine dosing information. Usual Adult Dose for Malaria Treatment of the acute attack 800 mg 620 mg base followed in 6 to 8 hours by 400 mg 310 mg base, then 400 mg 310 mg base once a day for 2 consecutive days; alternatively, a single dose of 800 mg 620 mg base has also been effective Hydroxychloroquine Uses, Dosage & Side Effects -. Plaquenil Dosage Guide -. Hydroxychloroquine Dosage Guide with Precautions -. Rheumatoid Arthritis. The action of hydroxychloroquine is cumulative and may require weeks to months to achieve the maximum therapeutic effect see CLINICAL PHARMACOLOGY. Initial adult dosage 400 mg to 600 mg 310 to 465 mg base daily, administered as a single daily dose or in two divided doses. Off-label use Rheumatoid arthritis, Systemic Lupus Erythematosus, primary Sjögren’s Syndrome extraglandular manifestations, inflammatory osteoarthritis; ADULT DOSING. 200-400 mg PO daily in a single or divided dose tablets are 200 mg. To reduce the risk of retinopathy, do not exceed 5 mg/kg/day or 400 mg PO daily. DOSE ADJUSTMENT Dosage for rheumatoid arthritis Adult dosage ages 18 years and older Typical starting dosage 400–600 mg per day, given as a single daily dose or in two 2 divided doses.