Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. What is hydroxychloroquine for Plaquenil icd9 Improvement of the hyperpigmentation a few months after hydroxychloroquine is stopped has been reported, but complete clearance is rare. 1 Cautious use of the Q-switched ruby laser has shown promise in the treatment of nonmelanotic hyperpigmentation in limited case reports. 5 Our patient’s skin discoloration partially resolved four months after switching to chloroquine. Hydroxychloroquine is a well-tolerated medication for various rheumatologic and dermatologic conditions. Its main side effects are gastrointestinal upset, skin rash, headache, and ocular toxicity1. Within the eye, hydroxychloroquine can adversely impact the cornea, ciliary body, and retina1 Purpose Hydroxychloroquine HCQ is a systemic antimalarial used to treat cutaneous and systemic lupus erythematosus and other connective tissue diseases. Mucocutaneous hyperpigmentation is a well-documented side effect of HCQ that occurs in 10-25% of users. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Hydroxychloroquine hyperpigmentation treatment Persistent cutaneous hyperpigmentation due to., Hydroxychloroquine toxicity - EyeWiki Chloroquine for malaria infection Hydroxychloroquine-associated hyperpigmentation in an elderly woman was clinically misinterpreted as elder abuse resulting in notification of Adult Protective Services by the clinician; skin biopsy subsequently confirmed the etiology of her diffuse black and blue dyschromia. Hydroxychloroquine-Associated. Treatment of hydroxychloroquine-induced hyperpigmentation.. Hydroxychloroquine-induced Hyperpigmentation of the Skin.. Using multivariate logistic regression, we found that HCQ-induced pigmentation was independently associated with previous treatment with oral anticoagulants and/or antiplatelet agents and with higher blood HCQ concentration. CONCLUSIONS AND RELEVANCE Hydroxychloroquine-induced pigmentation is not a rare adverse effect of HCQ. The patient was diagnosed with granuloma annulare GA and started on hydroxychloroquine HCQ 300 mg daily. After 4 months of treatment, she developed bluish grey pigmentation within the plaques of GA with normal surrounding skin figure 1A,B. There was no pigmentation at other body sites. Rare, previous reports of hyperpigmentation indicate the presence of both melanin and hemosiderin in patients being treated with antimalarial medication. To our knowledge, this staining pattern for hydroxychloroquine has not been previously reported in the literature and supports that hydroxychloroquine, in addition to chloroquine, binds to.