Malaria is a serious but rare disease caused by bites from infected mosquitos. Now the drug is used to treat inflammatory diseases. Chloroquine and piriton Interactions with plaquenil and fluconazole Hydroxychloroquine is a well-tolerated medication for various rheumatologic and dermatologic conditions. Its main side effects are gastrointestinal upset, skin rash, headache, and ocular toxicity1. Within the eye, hydroxychloroquine can adversely impact the cornea, ciliary body, and retina1 If you are taking Plaquenil to treat an inflammatory condition or malaria, you should be aware of the side effects that may occur to your eyes and vision. Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. Some diseases treated with Plaquenil include: Plaquenil lowers your immune system’s ability to cause inflammation. This type of disease occurs when the body's immune system attacks its own healthy tissue. Plaquenil effects on eyes Protecting your eyesight when taking Plaquenil Lupus., Plaquenil Side Effects on Your Eyes and Vision Plaquenil and celebrex interactionPlaquenil precioWhat are the side affects of hydroxychloroquine Plaquenil side effects. Get emergency medical help if you have signs of an allergic reaction to Plaquenil hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Taking Plaquenil long-term or at high doses may cause irreversible damage to the retina of your eye. Plaquenil Uses, Dosage & Side Effects -. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Hydroxychloroquine Oral Route Side Effects - Mayo Clinic. Please note the rare side effects listed below, specifically retinopathy, which causes damage to the eyes. Side effects associated with Plaquenil are placed in three categories common, less common, and rare. If you have any of the following effects and they persist or worsen, notify your doctor or pharmacist promptly. Chloroquine has been replaced with hydroxychloroquine as it has less side effects. Eye Exam Before Starting Treatment. If a person is going to be treated long-term with Plaquenil, they need to have a thorough dilated eye exam with best corrected visual acuity, central visual field, color vision, and dilated examination of the retina. Although rare, Plaquenil can cause significant toxicity to the eye with prolonged use. Also, Plaquenil may have various systemic side effects that are not related to the eyes. These too are rare and include nerve weakness, hallucinations, psoriasis and changes in hair color. The eye complications are the most serious and worrisome.