I know that the medication is known to cause weight loss and decreased appetite, but I've found that since starting treatment I've gained weight and nothing seems to budge it. Unfortunately, a LOT of the meds we're prescribed come with weight gain as a side effect (just ONCE I wish the side effects would be "become irresistible" but I've yet to hear about that drug trial)Usually it's an issue of one or two things (sometimes both). I've noticed on some forums folks have experienced this. If so, have you spoken with your rheum, changed your dosage, or found other ways to combat this side effect? Some of these drugs increase your appetite and cravings, some of them increase your water retention. Lorazepam and hydroxychloroquine What blood test are needed while on plaquenil Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Lynwood, I can't answer your question about weight gain or loss on plaquenil but I did go off plaquenil a few months ago and haven't been the same since. I regret the decision which had I made because I'd felt pretty well for quite some time and was doing my best to slowly get off as many meds as possible. If you're on steroids that can be whats causing you to gain weight. I can't offer any advice on losing the weight if you come off the Plaquenil. Like Joy said, Plaquenil is the first medication they use in treating lupus. It has the least amount of side effects and seems to work well for most patients. Some patients can not take the generic. This will stop your body from obsessively retaining water and making you feel and look puffy all over. In the case of the latter, it helps to GREATLY reduce your sodium intake and increase your water intake. Does plaquenil cause weight gain Plaquenil Hydroxychloroquine Side effects, Images, Uses., Plaquenil & Weight Gain/Loss - Can you take ibuprofen with plaquenilChloroquine 500mg tab I have been on plaquenil for many a year, and it has not affected my weight at all. If you go to or rxlist.com, neither of them list weight gain as a side effect, while they both list "nausea, vomiting, stomach pain; loss of appetite, weight loss" as side effects. Weight gain while on Plaquenil? lupus. Plaquenil and weight gain -. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur. Children's doses are based on body weight as prescribed by the doctor. To help reduce stomach upset, hydroxychloroquine should be taken with a meal or a glass of milk. Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. In rare cases, Plaquenil can cause cardiomyopathy, a chronic disease of the heart muscle. If you're taking Plaquenil for an autoimmune condition, your symptoms should begin to improve after a few.