But there's evidence the drug can activate a virus that can increase the risk of lymphoma and similar cancers in some patients. A number of reports have linked methotrexate with lymphoma and similar cancers of the lymph glands, says senior researcher Shannon C. Kenney, MD, a microbiologist and infectious disease specialist with the Lineberger Comprehensive Cancer Center at the University of North Carolina at Chapel Hill. Prednisone and plaquenil during pregnancy Side effects of starting plaquenil Side effects from plaquenil on eye Reddit plaquenil weight loss Combination therapy with methotrexate and hydroxychloroquine for rheumatoid arthritis increases exposure to methotrexate. Carmichael SJ1, Beal J, Day RO, Tett SE. Author information 1School of Pharmacy, University of Queensland, Brisbane, Australia. Administration of hydroxychloroquine with penicillamine Cuprimine, Depen may increase penicillamine levels, increasing the risk of penicillamine side effects. The mechanism is unknown. Hydroxychloroquine is sometimes combined with methotrexate for additive benefits for signs and symptoms or as part of a regimen of “triple therapy” with methotrexate and sulfasalazine. Mechanism The mechanism of action of antimalarials in the treatment of patients with rheumatoid arthritis is unknown but is thought to involve changes in antigen presentation or effects on the innate immune system. Some studies have indicated that the drug's immune-weakening effect places people at risk for viral-associated lymphomas. Also, studies have shown that when rheumatoid arthritis patients quit taking methotrexate, their lymphoma went into regression, another sign that the drug directly contributes to the cancer, she tells Web MD. Hydroxychloroquine increse methotrexate Hydroxychloroquine oral and methotrexate sodium oral Drug., Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria Carbamazepine with chloroquinePlaquenil and 5hr energy interactionsSulfasalazine taken with hydroxychloroquineHydroxychloroquine plaquenil rheumatoid arthritis Sorry to hear that you are having a lot of pain with your RA. I have lupus which mainly affects my joints and skin. I have been taking hydroxychloroquine which is the generic of plaquenil for the past three years. My rheumy recently added Imuran instead of methotrexate. Plaquenil hydroxychloroquine takes up to 3 months to begin working. Which would you pick and why? - Plaquenil or Methotrexate. Rheumatoid Arthritis Treatment Options Johns Hopkins.. Does anyone take methotrexate and hydroxychloroquine.. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Methotrexate Rasuvo, Otrexup is a self-injectable solution used to treat psoriasis and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as.