You get more ACE2 receptors though if you smoke or have diabetes or if you lige a place with a lot of air pollution.https://gov/pmc/articles/PMC2911869/https://gov/pmc/articles/PMC1287568/I'm not a doctor so this is to be taken as medical advise or a reason to skip any precautions. I'm also certain the scientists will learn much more and perhaps change their views later. Is plaquenil an immunosuppressant Can you chew plaquenil Plaquenil prescribing info Plaquenil didn't work for me. I take mtx as an injection because it made me feel sick for two days after I took the pills. The injection causes me to be very tired and I have gotten the runs from it. I usually take an extra folic acid pill the day I inject and it seems to ward off the runs. Vicki Plaquenil was a miracle drug for me. It began to work in 3 weeks and within 6 months my inflammation had gone from over 40 to 5.5. And I only took 200mg every other day! Plaquenil for fatigue and pain. Sunvalleygal 04/12/2013. My rheumy stated the plaquenil wouldn't help me.though he didn't say why. I take MTX and I'm also on tramadol for pain. No NSAIDs for me. I take Nsaids for pain to get me through a work day when I am having a tough time. It seems to me you should be on a Dmard. I only write it, because reading this made me feel less nervous and it might help others too. You should also note that a slighter risk does not equate to immunity and that other health factors may make you more or less susceptible. Plaquenil did not work for me Plaquenil questions. -, Hydroxychloroquine Reviews Everyday Health Plaquenil can& 39 Plaquenil hydroxychloroquine is commonly used to help keep mild lupus-related problems, such as skin and joint disease, under control. this drug is also effective at preventing lupus flares. How is plaquenil hydroxychloroquine used to treat lupus?. Plaquenil for fatigue and pain DailyStrength. Plaquenil Hydroxychloroquine for use in Autoimmune disease. Side.. Had headaches with the plaquenil so went to the sulfar and predisone. Sulfar was a waste of time and since I had a little help from the plaquenil he switched me back to that with pain meds for the headaches and body. Recently i went back for app. and plaquenil had stopped doing anything so he added the methotrexate to it. I did not want to take it. For me it did not start so quickly. You need to build a therapeutic level for any real benefit. Sometimes that is how Sjogren's works. Symptoms seem to disappear for a few days and reappear. Plaquenil eventually helped my joint pain. The continued fatigue and other symptoms are related to my mctd so I am not the perfect judge for this. Plaquenil didn't work for me. Methotrexate isn't so bad if you can deal with being stupidly tired and brain foggy one day a week, a day I dub "Methotrexate Hangover Day." Start with either, and keep in mind you may have to try a few different meds before you find one that works.