She had been taking hydroxychloroquine as a disease-modifying agent for about 15 years. A transthoracic echocardiogram showed reduced left ventricular function with an ejection fraction of 35% (A, Online Video 1). Accidently took next days dose of hydroxychloroquine Plaquenil causing worse asthma problems Hydroxychloroquine maculopathy Can plaquenil be used to trear lichen plnas This article is from June 2011 and may contain outdated material. Download PDF. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. Cardiac disorders Cardiomyopathy which may result in cardiac failure and in some cases a fatal outcome see WARNINGS and OVERDOSAGE. PLAQUENIL prolongs the QT interval. Ventricular arrhythmias and torsade de pointes have been reported in patients taking PLAQUENIL see OVERDOSAGE and DRUG INTERACTIONS. Clinical manifestations of antimalarial-induced cardiotoxicity can manifest as restrictive cardiomyopathy, dilated cardiomyopathy, or conduction abnormalities such as bundle branch and atrioventricular block. Patients usually present with HF symptoms. However, non-specific chest discomfort may be a presenting or coexisting feature. Periodic-acid Schiff staining showed glycogen deposition in myocyte cytoplasm. Subsequent coronary angiography revealed normal coronary arteries. Hematoxylin and eosin staining revealed myocyte vacuolization (B). Plaquenil induced cardiomyopathy Will you have Cardiomyopathy with Plaquenil - eHealthMe, Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Doxycycline and plaquenilPlaquenil hydroxychloroquine ocdPlaquenil visual field New clinical and ultrastructural findings in hydroxychloroquine-induced cardiomyopathy a report of 2 cases. Hum Pathol. 2007; 58–1863. Hydroxychloroquine-Induced Cardiomyopathy Circulation Heart Failure. Hydroxychloroquine-induced restrictive cardiomyopathy a case.. A Rare but Reversible Cause of Myopathy.. In conclusion, chronic use of hydroxychloroquine can result in an acquired lysosomal storage disorder, leading to a drug-induced cardiomyopathy characterized by concentric hypertrophy and conduction abnormalities associated with increased adverse clinical outcomes and mortality. Introduction. Hydroxychloroquine HCQ is one of the antimalarial drugs that have been used for decades to treat rheumatic diseases. Retinal toxicity, neuromyopathy, and cardiac toxicity are recognized toxicities following prolonged use. HCQ-induced cardiomyopathy is one of the rare but severe complications which could be reversible with early withdrawal of the drug. Hydroxychloroquine HCQ-induced cardiomyopathy is one of the rare but severe complications following prolonged HCQ use. However, the exact mechanism of HCQ cardiotoxicity remains unclear and it is difficult to identify risk factors. We present a case.