Treatment of chloroquine resistant falciparum malaria

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  1. SerGr Well-Known Member

    Treatment of chloroquine resistant falciparum malaria

    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    The adult treatment doses of chloroquine can be given for non-falciparum malaria. In the case of P. vivax or P. ovale, however, the radical cure with primaquine should be postponed until the pregnancy is over; instead chloroquine should be continued, given weekly during the pregnancy. Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. ovale, and P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. With doxycycline, tetracycline, or clindamycin, recommended as a preferred regimen for treatment of uncomplicated malaria due to chloroquine-resistant or unknown resistance P falciparum or species not identified; in pregnant women, this drug should be used with clindamycin.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Treatment of chloroquine resistant falciparum malaria

    Chloroquine-resistant falciparum malaria Responsiveness., Chloroquine - Wikipedia

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  3. Chloroquine-resistant malaria is exactly what it sounds like—particular types of malaria which are not cured by treatment with chloroquine. Chloroquine was first discovered in the 1930s in Germany and began to be widely used as an anti-malaria post-World War II, in the late 1940s.

    • Chloroquine Resistant Malaria –.
    • Quinine Dosage Guide with Precautions -.
    • High-Dose Chloroquine for Treatment of Chloroquine..

    Powell rd, brewer gj, alving as. studies on a strain of chloroquine-resistant plasmodium falciparum from colombia, south america. am j trop med hyg. 1963 jul; 9–512. eyles de, hoo cc, warren m, sandosham aa. plasmodium falciparum resistant to chloroquine in cambodia. am j trop med hyg. 1963 nov; 0–843. Development of resistance to chloroquine CQ and other drug treatment in Plasmodium falciparum malaria has led the World Health Organization WHO to change its recommendations to adopt artemisinin combination therapy ACT as the first-line drug for the treatment of P. falciparum malaria cases in most endemic countries. Chloroquine CQ was Pakistan's first-line treatment for uncomplicated falciparum malaria from 1950 to 2007 3. It remains first-line treatment for vivax malaria, so is still used for treating unconfirmed malaria and falciparum infections undetected by microscopy or misdiagnosed as vivax 2.

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