Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Can i take omeprazole with hydroxychloroquine Hydroxychloroquine sulfate bp csr If you aren’t responding to methotrexate after a two-month period, your rheumatologist may try some kind of combination therapy, such as adding sulfasalazine and hydroxychloroquine called triple therapy or adding a biologic drug such as etanercept Enbrel, adalimumab Humira, or infliximab Remicade. May 07, 2017 Plaquenil inhibits disease progression. That means, it keeps it from getting worse and progressing faster. We generally will not be able to tell it is doing anything unless we go off it and see how bad things can get -- which of course is not a recommend act! And, Plaquenil takes 2-3 months to build up in your system. Learn when your doctor might switch you to one of these drugs, and how to make the change. like methotrexate, sulfasalazine, hydroxychloroquine, or leflunomide. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Switching from methotrexate to plaquenil Plaquenil a possible treatment for Coronovirus., Plaquenil or Methotrexate? - Adverse effect of hydroxychloroquine Methotrexate vs plaquenil side effects long term and short term The only problem is the Plaquenil causes severe headaches that interfer with my daily activities also. But the Dr suggested I try Methotrexate instead. Methotrexate vs plaquenil side effects long term and short term. How You Can Work With Your Doctor to Switch Your RA Meds. Treating Rheumatoid Arthritis DMARDs vs. Biologics.. I am just SO sensitive to meds. I have bad leukopenia and had to d/c Methotrexate after 2 weeks because it pulled the WBC's too critically low. Irish and StephL, thank-you so much for you ideas. Irish, do you think that if this were an allergic response that it should have shown up on the 1st two attempts on the Plaquenil? I was diagnosed with RA in march and have been on increasing dose of methotrexate. Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Thanks Methotrexate MTX is currently the most frequently used drugs in the treatment of rheumatoid arthritis RA. The drug had been synthesized in 1948 and first tests to treat patients with psoriasis and RA were published in 1951. However, until the 1980s.