Hydroxychloroquine is a one of a number of drugs which have been used for many years in the treatment of malaria. Fortunately, it was discovered these drugs often are helpful in the treatment of various rheumatic diseases, particularly systemic lupus erythematosus (SLE or "Lupus") and rheumatoid arthritis. Chloroquine sulphate arthritis Plaquenil and advil Things That Happen When Lupus Flares Up 1. Joint pain. Joint pain is one of the first signs of lupus flare and it is very common. About 95% of people with lupus will have stiff or swollen joints at some time in the course of their disease. Joint pain in lupus can be mistaken for rheumatoid arthritis RA, but they are quite different. For. Is extreme fatigue a side effect of Plaquenil. results with Plaquenil with very little side affects. I'm reading reviews online and I'm starting to get. What is Plaquenil and what are its benefits for Sjögren’s patients? Plaquenil hydroxychloroquine is a medication that has been used for many years to help musculoskeletal symptoms and fatigue in patients with autoimmune conditions such as rheumatoid arthritis, lupus and Sjögren’s. When effective, it can decrease damage to the tissues of the joints, skin and other organs in the body. Although chloroquine is sometimes used, the preferred antimalarial drug is hydroxychloroquine due to its greater safety. It is not possible at the present time to explain precisely why hydroxychloroquine is effective in various rheumatic diseases. Plaquenil for lupus reviews fatigue Does plaquenil help with fatigue. DailyStrength, Is extreme fatigue a side effect of Plaquenil - NRAS Is hydroxychloroquine safe to take while breastfeeding Hallucinated, broke out in rashes and crying spells. It was the worst 2 months of these side effects I've ever had in my life! Got off of it and I feel back to normal. My Lupus is mild so I'm going the holistic route. Plant based diet, acupuncture, juicing. I feel good and will take minor aches and fatigue any day than being on plaquenil. Beware! Plaquenil Drug and Medication User Reviews on RxList. Ask the Expert Plaquenil and Sjögren’s. Plaquenil oral Reviews and User Ratings Effectiveness, Ease.. Hi! I think Plaquenil is the cause of my extreme fatigue too. I am not anemic at this time and I get exhausted just trying to get through the day. I have also been on Plaquenil about three months. All of my arthritis swelling and pain are gone, but the fatigue will not let up! Hope things change for you. Diagnosed with Lupus at age 50 after lots of misdiagnosed ailments. First on prednisone and then told steroid was only temp reduce swelling and Plaquenil prescribed and started at 200 mg twice per. User Reviews for Hydroxychloroquine to treat Systemic Lupus Erythematosus. Also known as Plaquenil, Quineprox. The following information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners. Overview.