This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. For prevention of malaria in adults, one dose is usually taken once a week on exactly the same day of the week. Chloroquine drug indication Artemisia annua taken with hydroxychloroquine Resistance to currently available antimalarial drugs has been confirmed in only two of the four human malaria parasite species, Plasmodium falciparum and P. vivax. It is unknown if P. malariae or P. ovale has developed resistance to any antimalarial drugs. A standardized in vivo test protocol for assessing the response of P. falciparum to chloroquine was first developed in 1965 and after many revisions, the latest protocol has been put forth by the WHO in 2003.22 It involves a fairly simple, prospective evaluation of the clinical and parasitological response to treatment for uncomplicated malaria. Development of Chloroquine Resistance in Plasmodium falciparum. Drug resistance is the ability of a parasite to survive despite the presence of a drug that is meant to kill it in toxic levels. Resistance developed by most parasites that were initially sensitive to drugs mostly result from mutations in the genes responsive to the drug. One dose is taken beginning 2 weeks before traveling to an area where malaria is common, while you are in the area, and then for 8 weeks after you return from the area. Your doctor will tell you how many tablets to take for each dose. Chloroquine resistance testing ARALEN CHLOROQUINE PHOSPHATE, USP Label, Drug Resistance – Malaria Site Plaquenil a preventive medicineAralen side effects and instructionsPlaquenil reviews rheumatoid arthritis Resistance to chloroquine of malaria strains is known to be associated with a parasite protein named PfCRT, the mutated form of which is able to reduce chloroquine accumulation in the digestive vacuole of the pathogen. On the Mechanism of Chloroquine Resistance in Plasmodium.. Chloroquine Resistance in Plasmodium falciparum - microbewiki. Chloroquine Oral Uses, Side Effects, Interactions, Pictures.. Chloroquine is an aminoquinoline that is quinoline which is substituted at position 4 by a 5-diethylaminopentan-2-ylamino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis. Your doctor may order certain lab tests to check your response to chloroquine phosphate. Your doctor will also test your reflexes to see if you have muscle weakness that may be caused by the drug. If you are taking chloroquine phosphate for a long period of time, your doctor will recommend frequent eye exams. Chloroquine needs to be taken 1-2 weeks before traveling to an area with malaria, compared to some alternatives that can be taken 1-2 days before. chloroquine is only effective against malaria from certain areas of the world. chloroquine may worsen psoriasis, seizures, hearing problems, and liver conditions.