As with primaquine, tafenoquine can cause severe hemolytic anemia in people with G6PD deficiency. Those with partial deficiency that may be missed by qualitative testing may also be at risk for hemolysis. Painful muscle spasms from plaquenil Plaquenil somnolence Plaquenil sulfa drug Icd10cm code for plaquenil If used for the radical cure of P. vivax malaria, Krintafel tafenoquine should be co-administered with chloroquine only. This is a change from the original Krintafel labeling that allowed for use of Krintafel in combination with other antimalarials artemether-lumefantrine, atovaquone-proguanil, quinine plus doxycycline. Chloroquine binds to heme or FP to form the FP-chloroquine complex; this complex is highly toxic to the cell and disrupts membrane function. Action of the toxic FP-chloroquine and FP results in cell lysis and ultimately parasite cell autodigestion. Tafenoquine is an aminoquinoline that is used in combination with other antimalarials for the prevention of relapse of Plasmodium vivax malaria and by itself as prophylaxis against all species of malaria. Tafenoquine has been linked to low rates of transient and asymptomatic serum enzyme elevations during therapy but has not been associated with instances of clinically apparent acute liver injury. Tafenoquine use in people with G6PD deficiency or unknown G6PD status is contraindicated. Therefore, physicians must perform G6PD testing before prescribing tafenoquine. Act with chloroquine tafenoquine Interactions between tafenoquine and artemisinin., Chloroquine - Wikipedia Hydroxychloroquine brandsHow to take plaquenil twice daily Tafenoquine is in development as a single-dose treatment for relapse prevention in individuals with Plasmodium vivax malaria. Tafenoquine must be coadministered with a blood schizonticide, either chloroquine or artemisinin-based combination therapy ACT. Pharmacokinetic Interactions between Tafenoquine and.. Tafenoquine C24H28F3N3O3 - PubChem. Guidance for Using Tafenoquine for Prevention and.. Provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex updated, Cerner Multum™ updated, Wolters Kluwer™ updated. Tafenoquine is an investigational medicine that has completed phase III studies. If approved, it would be the first new medicine for relapsing malaria in over 60 years. Tafenoquine will potentially offer a single-dose cure for the liver-stage of P. vivax infections and will be administered alongside a standard 3-day chloroquine or potentially an ACT treatment regimen. The limited evidence available supports both the use of chloroquine and an ACT for P. ovale and P. malariae. ACT seems to be preferable for optimal treatment of P. knowlesi. ACT is at least equivalent to chloroquine in effectively treating non-falciparum malaria.