I can't say that the drug has helped at all, but it is difficult to compare todays pain with that of 6 months ago. Still get mysterious rashes, fevers and other odd symptoms. Asked my primary to check my thyroid after taking a bovine herbal thyroid med for 2 weeks. Then they worked out it was my liver causing my liver and that I could go back on Plaquenil. I have gained nearly 25 lbs now and I can' t stand it, but when I try an dexercise it is as if my muscles just will not relax, the are tight and it hurts to even do the lightest yogo! I took 60mg for a year and only 30 this past month. NOw if my thyroid isn't working I've hidden it from my dr... Well, within 3 days my non-liver symptoms were way better. Plaquenil for inflammatory osteoarthritis Id 10 code for plaquenil Is hyd chloroquine static or cidal Digoxin chloroquine Lupus arthritis causes pain, stiffness, swelling, tenderness and warmth in your joints. The joints most often affected are the ones farthest from the middle of the body, such as fingers, wrists, elbows, knees, ankles and toes. Hi, although Plaquenil is prescribed for autoimmune diseases, such as yours, it can actually add to/increase the number of the symptoms. Muscle damage and leg pain being just 2 examples. It is great that you have responded so well to the new medication. Hello all, I am currently new to this site and ran across the discussion about stopping Plaquenil. I have been taking Plaquenil for about 8-9 months and thought that it was not helping me because I still have a fair amount of joint pain, fatigue, muscle pain and so many other issues. I saw a rheumatologist who said "no the nausea is at the start before you get use to it etc, but just come off it for 2 weeks to 'prove this doctor wrong'". Don't know what I was thinking but my thyroid showed 1.59 (0,47-4.68)... Since then I've had one flare up of my hips and finger joints, which lasted for about 2-3 days (typically my flares last a few weeks). I'd say they're 90-95% better than this time last year. Plaquenil cause muscle pain Plaquenil and pain" Rheumatoid Arthritis Community., Hydroxychloroquine - thigh muscle weakness? Plaquenil and amoxicillinPlaquenil dosing mouseHydroxychloroquine food cravingsItching from plaquenilGluten free plaquenil RARE side effects. If experienced, these tend to have a Severe expression. Abnormal Liver Function Tests. Acute Liver Failure. Acute Pustular Eruptions On Skin. Bronchospasm. Decreased Blood Platelets. Decreased White Blood Cells. Common and Rare Side Effects for Plaquenil Oral. Stopping plaquenil. DailyStrength. Experiences taking Plaquenil for Fatigue and Muscle Pain.. Sep 24, 2010 I went in to my Rheum this week because I was having a lot more pain, burning, and muscle fatigue, particularly in my legs and arms, especially at night while I'm trying to sleep. He told me to stop the Plaquenil because sometimes it can cause nerve damage. He told me to stop it for two weeks and come back in. He said nerve damage is a side effect. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Plaquenil and Muscle aches - from FDA reports Summary Muscle aches is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 1 month, also take medication Enbrel, and have Pain.