The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. This virus infects more than 95 percent of people in the United States. Listing a study does not mean it has been evaluated by the U. Most are infected in childhood, have no symptoms, and are unaware of their infection. This study will examine the effects of long-term antiviral therapy with valaciclovir (Valtrex) on Epstein-Barr virus infection. People infected as adolescents or adults may develop infectious mononucleosis, which usually resolves completely. Once infected, most people shed the virus from their throat occasionally, and all carry the virus in their white blood cells for life. This study will determine whether the amount of virus in the blood declines or disappears with long-term valaciclovir treatment. Normal volunteers who are not taking any antiviral medicines and patients enrolled in NIH's protocol no. Kathryn Meininger began writing and publishing poetry in 1967. She was co-founder and editor of the professional magazine "Footsteps" and began writing articles online in 2010. She earned a Doctor of Podiatric Medicine from Temple University School of Podiatric Medicine and a Bachelor of Arts in biology from William Paterson University. View Full Profile Valtrex can affect kidney function, resulting in kidney failure. Valtrex, taken orally or intravenously, can lead to renal toxicity and renal failure in some who take the drug long term. According to the American Social Health Association, Valtrex converts to acyclovir as it is metabolized, and may crystallize out within the renal tubules, leading to renal toxicity and failure. Inadequate hydration can increase the chances for kidney failure, so drink plenty of water to keep your kidneys hydrated while taking Valtrex. Metformin monograph Fluconazole side effects in women Cialis oral gel Apr 1, 2018. Like any other medicine, Valtrex's success and effect is down to its active. It's not less effective if you take it short term or long term, as it is. Long-Term Side Effects of Valtrex. Kathryn Meininger. Valtrex, generic name valacyclovir, is an antiviral prescription medication used to treat some herpes. The aim of study was to determine the effectiveness, safety and side effects of suppressive therapy valacyclovir for relapsing genital herpes virus infections. Valacyclovir is used to treat infections caused by certain types of viruses. In children, it is used to treat cold sores around the mouth (caused by herpes simplex) and chickenpox (caused by varicella zoster). In adults, it is used to treat shingles (caused by herpes zoster) and cold sores around the mouth. The viruses that cause these infections continue to live in the body even between outbreaks. Valacyclovir is also used to treat outbreaks of genital herpes. Valacyclovir decreases the severity and length of these outbreaks. In people with frequent outbreaks, this medication is used to reduce the number of future episodes. It helps the sores heal faster, keeps new sores from forming, and decreases pain/itching. This medication may also help reduce how long pain remains after the sores heal. Read the Patient Information Leaflet if available from your pharmacist before you start taking valacyclovir and each time you get a refill. An extensive clinical trial program combined with 5 years’ postmarketing experience with valacyclovir provides evidence of favorable safety and efficacy in herpes simplex virus (HSV) management. Valacyclovir enhances acyclovir bioavailability compared with orally administered acyclovir. Long-term use of acyclovir for up to 10 years for HSV suppression is effective and well tolerated. Acyclovir is also approved for use in children, is available in some countries over the counter in cream formulation for herpes labialis, and has been monitored in over 1000 pregnancies. Safety monitoring data from clinical trials of valacyclovir, involving over 3000 immunocompetent and immunocompromised persons receiving long-term therapy for HSV suppression, were analyzed. Safety profiles of valacyclovir (⩽1000 mg/day), acyclovir (800 mg/day), and placebo were similar. Extensive sensitivity monitoring of HSV isolates confirmed a very low rate of acyclovir resistance among immunocompetent subjects ( Five years after the licensing of valacyclovir and two decades after the introduction of acyclovir, a wealth of data has been generated on the clinical utility of this selective antiherpes agent and its prodrug. Valtrex long term side effects Valaciclovir - Wikipedia, Long-Term Side Effects of Valtrex Ciprofloxacin what is it In worst cases, this can lead to permanent damage and blindness. Valacyclovir rarely causes side effects, appears safe to use during pregnancy, and offers. Herpes Zoster Virus shingles - POZ. Evaluation of safety and efficacy of prolonged suppressive therapy of.. Alcohol and Valtrex Can You Drink Alcohol While Taking Valtrex?. Nov 14, 2014. The side effects of Valtrex may be more severe in older adults. have any side effects that I should be concerned about over the long-term? Information for Valtrex Oral on WebMD including its uses, side effects and. This medication may also help reduce how long pain remains after the sores heal. Valacyclovir hydrochloride is the L-valyl ester of acyclovir, and is available and effective in. and long-term acyclovir or related antivirals possibly reduce the risk for. Pietro L. Vernazza, Patrick Schmid, in Side Effects of Drugs Annual, 2005.