Regardless of the problem, we'd like to help you find what you're looking for. I've been taking Plaquenil 400 mg for nearly 6 mos. Dose of hydroxychloroquine for ra Chloroquine peak plasma concentraion Hydroxychloroquine poisoning Plaquenil and calcium citrate About a month ago, I finally decided to start taking the Plaquenil. I took 100 mg daily for a week since I'm highly sensitive to new medications, with the goal of reaching 400 mg daily after three weeks. One of my most bothersome symptoms is muscle weakness and fatigue, and the Plaquenil seemed to exacerbate it dramatically. Side effects include irritability, headache, weakness, hair lightening or loss, stomach upset, nausea, dizziness, muscle pain, rash and itching. Rarely, hydroxychloroquine can affect the bone marrow leading to reduced white blood cells leukopenia or platelets thrombocytopenia and abnormal red blood cells but potentially serious eye toxicity can occur. Muscular weakness is found among people who take Fluconazole and Plaquenil, especially for people who are female, 60+ old, have been taking the drugs for 6 - 12 months, also take medication Lisinopril, and have Antibiotic therapy. This review analyzes which people have Muscular weakness with Fluconazole and Plaquenil. But now I've been dealing with considerable muscle aching and pain/spasm in some new places - or at least places that haven't bothered me in quite awhile. I didn't seem to have any problems whatsoever with it initially, other than very short term and mild cramping/diarrhea. Plaquenil and muscle weakness Can Plaquenil cause Muscle Weakness? - Treato, Hydroxychloroquine Plaquenil Side Effects & Dosage for. Using hydroxychloroquine and leflunomide togetherChloroquine resistant vivax malaria treatment Plaquenil antibiotics are part of the fluoroquinolone antibiotics. Muscle weakness is a side effect. I would be very cautious! Quinolone antibiotics are chemotherapeutic and late side effects months to years later are common. Plaquenil weakness - Road Back Foundation. Fluconazole and Plaquenil drug interaction Muscular weakness.. Hydroxychloroquine - Wikipedia. I have PMR, but to get me to try to taper steroids, the rheum started me on generic Plaquenil. My right thigh muscle hurts, and walking up stairs is an issue - I can do it, but it hurts. I am trying to think back to if this was an issue when I was not on the Plaquenil - I have been on it for 4-5 months now, so it's hard to remember. Moved Permanently. The document has moved here. Muscle biopsy leads to a final diagnosis in most people with myositis. There are many causes of muscle weakness and pain more common than myositis, and testing for myositis is not a.