Most importantly, you help support continued development of this site. The majority of cases of retinotoxicity have occurred in patients that have had a cumulative dose exceeding 1000g of hydroxychloriquine (Plaquenil). This level is reached in about 7 years with the most common daily dose of Plaquenil, 400 mg/day (200 bid). What are the rates of plaquenil Hydroxychloroquine 400 mg tablets Yes, it is standard to have an ophthalmologist exam every 6 mths or 1 yr when taking Plaquenil. My rheumy says 1 yr is ok, as problems very seldom develop. I don't know of anyone here who has had any problems. If you are taking Plaquenil to treat an inflammatory condition or malaria, you should be aware of the side effects that may occur to your eyes and vision. Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. Conclusions We identified HCQ in toxicity 1.7 % and bull's eye lesions in 0.7%.92.3% of patients are in high or very high-risk categories. Risk categories appeared to be weakly related to observed toxicity. There was no relation between risk categories and screening examination frequency. It now solely uses real body weight (rather than ideal body weight) based on new recommendations from a 2014 study (1). Disclaimer: This tool is designed to help eye care professionals better understand the risk the of retinotoxicity from hydroxychloroquine. Please note: This calculator was modified in 9/2015. Hydroxychloroquine eye exam frequency Plaquenil Risk Calculators, Plaquenil Side Effects on Your Eyes and Vision How often do you take plaquenil On examination, a telltale sign of hydroxychloroquine toxicity is a bilateral change in the retinal pigment epithelium of the macula that gives the commonly described appearance of a bull’s-eye. This is a late finding, however, and too late for screening to be useful. Hydroxychloroquine-Induced Retinal Toxicity - American.. Hydroxychloroquine HCQ Eye Examination Frequency.. New Plaquenil Guidelines. Background The American Academy of Ophthalmology recommendations on screening for chloroquine CQ and hydroxychloroquine HCQ retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. A 26-year-old black female presented in office for her annual comprehensive eye exam. Her medical history was significant for Plaquenil therapy spanning 12 years with a daily dose of 200mg twice daily. She presented with a best-corrected visual acuity of 20/20 OD and 20/20 OS. All preliminary testing revealed normal findings. A cumulative dose of 1000g of hydroxychloroquine or 460g of chloroquine was likely the largest risk factor, which was typically achieved after 5-7 years of a typical dosage 8, 10. However, there have been case reports of patients with hydroxychloroquine toxicity as early as 1.9 months after starting treatment 11.