Chloroquine maculopathy

Discussion in 'Canada Drug' started by FeelMan, 26-Feb-2020.

  1. SeoPro! Moderator

    Chloroquine maculopathy


    She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation.

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    Chloroquine phosphate tablets should not be used in these conditions unless the benefit to the patient outweighs the potential risks. Usage in Pregnancy Usage of Chloroquine during pregnancy should be avoided except in the prophylaxis or treatment of malaria when the benefit outweighs the potential risk to the fetus. Some patients, toxicity may first present as pericentral retinopathy and thus requires screening outside the macula. We assume chloroquine retinopathy follows a similar course as hydroxychloroquine retinopathy and so these guidelines also apply to patients taking chloroquine therapy. Jan 05, 2020 Hydroxychloroquine Plaquenil and chloroquine cause ocular toxicity to various parts of the eye such as the cornea, ciliary body, and retina. Chloroquine can also induce cataract formation; however, no reports of hydroxychloroquine and cataract have been reported 1.

    Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use.

    Chloroquine maculopathy

    Hydroxychloroquine retinopathy Eye, Hydroxychloroquine and Chloroquine Retinopathy.

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  4. Chloroquine and hydroxychloroquine can cause toxic retinopathy due to their binding of melanin in the retinal pigmented epithelium RPE as well as direct toxicity to retinal ganglion cells. Early findings include mottling of the RPE and blunted foveal reflex. As the retinopathy progresses, a bull's-eye maculopathy develops, as seen in these.

    • Bull's-eye maculopathy due to hydroxychloroquine toxicity.
    • Hydroxychloroquine toxicity - EyeWiki.
    • Hydroxychloroquine - Wikipedia.

    A cumulative dose of 1000g of hydroxychloroquine or 460g of chloroquine was likely the largest risk factor, which was typically achieved after 5-7 years of a typical dosage 8, 10. However, there have been case reports of patients with hydroxychloroquine toxicity as early as 1.9 months after starting treatment 11. Chloroquine and its derivative, hydroxychloroquine sulfate, which have been useful in treating malaria and in larger doses, collagen-vascular disease, cause a cumulative dose-related pigmentary retinopathy. The Academy uses cookies to analyze performance and provide relevant personalized content to users of our website. The American Academy of Ophthalmology released an updated set of screening recommendations for hydroxychloroquine Plaquenil and chloroquine to account for the many studies that have shown the effects of these medications on the retina 1. It succinctly makes the case for screening, and

     
  5. legotin Well-Known Member

    Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. What Is the Difference between Hydroxychloroquine and Chloroquine? Plaquenil Oral Uses, Side Effects, Interactions, Pictures, Warnings. Plaquenil Side Effects on Your Eyes and Vision
     
  6. musicofil XenForo Moderator

    Diagnosis and Treatment of Pain in Small Fiber Neuropathy A small fiber neuropathy occurs when damage to the peripheral nerves predominantly or entirely affects the small myelinated Aδ fibers or unmyelinated C fibers. The specific fiber types involved in this process include both small somatic and autonomic fibers. The sensory functions of these fibers include thermal perception and nociception.

    Plaquenil and nerve damage - Scleroderma - Inspire
     
  7. nikarina5 User

    Experiences with Plaquenil? ProHealth Fibromyalgia, ME. I've had CFS since January 2003 with no positive response to many treatments so far. My rheumatologist just prescribed Plaquenil and has high hopes it will do me some good. I was told it's used to treat Malaria but now has off-label use in people with suspected immune deficiencies. My doctor.

    Hydroxychloroquine Plaquenil